OBJECTIVE: To examine the predictive value of the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) index with regard to future radiographic osteoarthritis (OA). METHODS: In 1998, 17 knees in 11 men and 4 women with knee pain, normal results of weight-bearing radiography, and arthroscopic cartilage changes ranging from superficial fibrillation to fissuring and

10 List of Papers I Tiderius C J, Tjörnstrand J, Akeson P, Sodersten K, Dahlberg L, Leander P. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): intra- and interobserver va

The baseline dGEMRIC index correlated with the improvement in the WOMAC score 1 year postoperatively. differences in the dGEMRIC index across a region were used to predict difference in stiffness. The dGEMRICindexishighlycorrelatedtomechanicalstiffness.Ageneralizedrelationshipwasfoundto providegoodcorrespondenceacrosssourcesandregions.UseofthedGEMRICindexasapredictive measureofstiffnessispossible,dependingontheapplication’sacceptableerror. The dGEMRIC index was assessed on MRI according to established protocol. Regression analysis adjusted for age, sex, body mass index (BMI), and presence of clinical knee OA. Mean age and BMI were dGEMRIC index in the medial weight-bearing cartilage. Conclusions: The higher pre-contrast T 1 in the superficial region than in the deep region is an indication of a higher water content in superficial cartilage. The uptake of contrast was found to be from the superficial region of In the posterosuperior quadrant, the dGEMRIC index was higher for patients with intact cartilage compared with hips with chondral lesions (592 ± 203 ms versus 444 ± 205 ms, p < 0.001).

Methods One hundred and forty-eight women (one knee for each subject) aged ≥40 years were included To compare the delayed gadolinium-enhanced magnetic resonance (MR) imaging of cartilage (dGEMRIC) indexes acquired with different gadolinium-based contrast agents (GBCAs), with emphasis on the difference in electrical charge, and to evaluate the feasibility of the use of GBCAs other than gadopentetate dimeglumine with a double negative charge (Gd-DTPA 2−) as alternatives at dGEMRIC. average dGEMRIC index as well as slice 2, as an early measure of OA, appears to help identify patients who will not benefit from a joint reconstruction procedure. We show that the analysis of one central slice over the hip joint (slice 2) provides similar information as the average dGEMRIC index of all hip joint cartilage. low dGEMRIC index in the repair tissue two years postoperatively indicated fibrocartilage of low quality.

The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) index is highly correlated to mechanical stiffness, and, although not as good as a direct mechanical measurement, the index can be used as a predictive measure of stiffness. 2021-03-19 2012-01-01 Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) reflects cartilage glycosaminoglycan (GAG) distribution.

The patients were divided into two groups on the basis of their dGEMRIC index. This division was established by ﬁrst calculating the mean and SD of the dGEMRIC indices of all of the study cohort patients. Then patients were grouped according to whether they were less than one SD or at least one SD below the mean dGEMRIC index of 426 msec.

Copyright (c) 2007 Orthopaedic Research Society. PMID: 17427215 2006-11-01 · The mean T1 (Gd) within a clinically relevant region of articular cartilage is usually referred to as the dGEMRIC Index 6. In the current dGEMRIC protocol, Gd-DTPA 2− is administered per kilogram body weight with the assumption that the distribution volume of the contrast agent is proportional to body weight. We found that the dGEMRIC index decreased to a substantially higher degree in operatively treated patients with FAI compared with nonoperative management at 1-year followup.

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2018-06-02 2016-10-05 BACKGROUND Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) allows an objective, noninvasive, and longitudinal quantification of biochemical cartilage properties. Although d Table 2. average dgeMriC indices (in Milliseconds) for the 12 regions of interest, the Medial and lateral Compartments at Baseline and after Follow-up. - "Cartilage Quality (dGEMRIC Index) Following Knee Joint Distraction or High Tibial Osteotomy" less. Thus, a higher dGEMRIC index indicates healthier cartilage (Fig. 1)[59]. Similar to the knee [4, 34], dGEMRIC is a promising tool to quantify cartilage healing or degeneration before and after joint-preserving hip sur-gery and to monitor the natural course of hip diseases.

Broschområden med lägre dGEMRIC-index observeras vanligtvis i leder där som T2, T1rho, ultrashorteko och dGEMRIC-tider ännu inte klart fastställda 12, 13 . och Approach population studies (//www.hjartarannsokn.is/index.aspx? Acetabular index är en uppskattning av mängden avvikelse mellan kavitetens tak användes förutom morfologisk information dGEMRIC T1- och T2-kartor, som molekylär brosksammansättning, dGEMRIC (delayed Gadolinium-enhanced WOMAC Lequesne Index Lequesne Index (¨Rescue¨ medicinering ej tillåten) Quality (dGEMRIC Index) Following Knee Joint Distraction or High Tibial Osteotomy by Nick J. Besselink, Koen L. Vincken, L. Wilbert Bartels, Ronald J. van Heerwaarden, Arno N. Concepcion, Anne C. A. Marijnissen, Sander Spruijt, Roel J. H. Custers, Jan-Ton A. D. van der Woude, Karen Wiegant, Paco M. J. The average dGEMRIC index refers to the longitudinal relaxation time in the presence of gadolinium-based contrast agent. Voxel-wise fitting of the dGEMRIC signal using the Levenberg-Marquardt nonlinear least-squares method with in-house developed software (R2015a, The MathWorks, Natick, MA, USA) produced a reconstructed T1 map.
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An intraobserver analysis for T1 analysis was made in 10 randomly selected SCFE hips. The alpha angle was measured in T1 parasagittal images as defined by Nötzli 24 . Table 2. average dgeMriC indices (in Milliseconds) for the 12 regions of interest, the Medial and lateral Compartments at Baseline and after Follow-up.

lesion on the femoral head or neck exists. The dGEMRIC is evaluated for labral tears, chondral ﬂaps, bony edema, and the dGEMRIC index. Patients with joint space narrowing or signiﬁcant chondral injury are not considered for PAO. Patients with mild dysplasia, a lateral center-edge angle of 20 to 25 , may be considered for arthroscopy alone. Cartilage) Index distribution in the human knee.
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A negative correlation between the dGEMRIC index in the adjacent cartilage and future OA suggests that the quality of the surrounding cartilage

2016-10-05 Results: The mean dGEMRIC index (and standard deviation) for this cohort (473 +/- 104 msec) was significantly lower than that of a morphologically normal hip (570 +/- 90 msec). The anterior center-edge angle, the joint space width, and the presence of a labral tear were all found to be associated with osteoarthritis in the univariate analysis. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was first described in 1996 as a nondestructive technique for quantitative measurements of glycosaminoglycan (GAG) concentration in articular cartilage samples [].Its translation to clinical platforms as a means of interrogating the molecular aspects of cartilage was demonstrated in 1997 with illustrative examples of apparent … The dGEMRIC index was assessed on MRI according to established protocol.

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The dGEMRIC index was assessed on MRI according to established protocol. Regression analysis adjusted for age, sex, body mass index (BMI), and presence of clinical knee OA. Mean age and BMI were

Methods 3D rendering of the cartilage surface using the techniques descried by Tamez-Pena [1] was applied to 3D dGEMRIC images of the knee.

The mean T1 (Gd) within a clinically relevant region of articular cartilage is usually referred to as the dGEMRIC Index 6. In the current dGEMRIC protocol, Gd-DTPA 2− is administered per kilogram body weight with the assumption that the distribution volume of the contrast agent is proportional to body weight.

Furthermore, dGEMRIC is sensitive enough to show dif- In a previous dGEMRIC study using bulk (full-thickness) index values, we found higher dGEMRIC index interpreted as better cartilage quality in exercising compared to sedentary healthy volunteers . To examine the impact of recently described confounding factors in dGEMRIC, we now have performed a detailed re-analysis of our data including T1 pre contrast and cartilage thickness measurements. dGEMRIC indices similar to those from their matched controls and in the normal range for hip cartilage.

The technique assumes that the plasma levels of the contrast agent Gd-DTPA2− are the same across individuals after intravenous (IV) injection, when dosing by weight. However, adipose tissue has lower extracellular water (ECW) than lean tissue.